Journal of Stroke

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Review

May 31, 2025

The Association of Lipoprotein(a) and Stroke Recurrence: A Systematic Review and Meta-Analysis

Lina Palaiodimou, Konstantinos Melanis, Maria-Ioanna Stefanou, Aikaterini Theodorou, Sotirios Giannopoulos, Vaia Lambadiari, Diana Aguiar de Sousa, Simona Sacco, Mira Katan, Gerasimos Siasos, et al.

J Stroke. 2025;27(2):161-168.

Background and Purpose Lipoprotein(a) [Lp(a)] is a lipoprotein structurally similar to low-density lipoprotein and is considered a genetically determined risk factor for cardiovascular disease. Although Lp(a) has been linked to...

Review

May 31, 2025

Carotid Web: An Update Focusing on Its Relationship With Fibromuscular Dysplasia and Therapeutic Strategy

Marialuisa Zedde, Maria Simona Stoenoiu, Alexandre Persu, Rosario Pascarella

J Stroke. 2025;27(2):169-183.

Carotid web was described more than 50 years ago as an atypical fibromuscular dysplasia (FMD) subtype with highly supporting pathological evidence as intimal FMD. In the following decades, the transition...

Review

May 31, 2025

Tenecteplase Beyond 4.5 Hours in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Mohammad Aladawi, Mohammad T. Abuawwad, Mohammad J. J. Taha, Yasmeena Abdelall Kozaa, Warda A. Alrubasy, Abdullah Hamad, Fatema Ahmad Alhnidi, Mohamed Elfil, Zaid Najdawi, Xiaohan Peng, et al.

J Stroke. 2025;27(2):184-194.

Background and Purpose Acute ischemic stroke (AIS) is a leading cause of disability worldwide. While intravenous thrombolysis is recommended within 4.5 hours of last known well (LKW) time, many patients...

Review

May 31, 2025

Anticoagulation Failure in Stroke: Causes, Risk Factors, and Treatment

Youngbin Choi, Jong S. Kim

J Stroke. 2025;27(2):195-206.

Anticoagulation is crucial to reducing the risk of cardioembolic strokes, particularly in vulnerable populations such as patients with atrial fibrillation, artificial heart valves, or left ventricular thrombus. Though successful, anticoagulation...

Original Article

May 31, 2025

Residual Inflammatory Risk and Intracranial Atherosclerosis Plaque Vulnerability: Insights From High-Resolution Magnetic Resonance Imaging

Ying Yu, Rongrong Cui, Xin He, Xinxin Shi, Zhikai Hou, Yuesong Pan, Mingyao Li, Jiabao Yang, Zhongrong Miao, Yongjun Wang, et al.

J Stroke. 2025;27(2):207-216.

Background and Purpose This study aimed to investigate the association between residual inflammatory risk (RIR) and vulnerable plaques using high-resolution magnetic resonance imaging (HRMRI) in symptomatic intracranial atherosclerotic stenosis (ICAS). Methods...

Original Article

May 31, 2025

Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis

Alexandros A. Polymeris, Masatoshi Koga, Daniel Strbian, Adhiyaman Vedamurthy, Manju Krishnan, Mattia Branca, Thomas Horvath, Martina Goeldlin, Gek Shim, Christoph Gumbinger, et al.

J Stroke. 2025;27(2):217-227.

Background and Purpose Antiplatelets are often used before direct oral anticoagulant (DOACs) initiation after an acute ischemic stroke related to atrial fibrillation (AF), but the evidence is weak. Here, we...

Original Article

May 31, 2025

Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial

Hanim Kwon, Jae-Chan Ryu, Jae-Kwan Cha, Sang Min Sung, Tae-Jin Song, Kyung Bok Lee, Eung-Gyu Kim, Yong-Won Kim, Ji Hoe Heo, Man Seok Park, et al.

J Stroke. 2025;27(2):228-236.

Background and Purpose The Treat Stroke to Target (TST) was a randomized clinical trial involving French and Korean patients demonstrating that a lower low-density lipoprotein cholesterol (LDL-C,

Original Article

May 31, 2025

Aldehyde Dehydrogenase 2 Gene Mutation May Reduce the Risk of Rupture of Intracranial Aneurysm in Chinese Han Population

Xiheng Chen, Siming Gui, Dachao Wei, Dingwei Deng, Yudi Tang, Jian Lv, Wei You, Jia Jiang, Jun Lin, Huijian Ge, et al.

J Stroke. 2025;27(2):237-249.

Background and Purpose Ruptured intracranial aneurysms (RIA) are associated with a mortality rate of up to 40% in the Chinese population, highlighting the critical need for targeted treatment interventions for...

Current Issue: Volume 27(2); May 2025

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Volume 27(2); May

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	Editorial Office Department of Neurology, Asan Medical Center,Ulsan University College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Submission, status and progress, etc ⟫ E-mail: editor@j-stroke.org Website and system ⟫ E-mail: journal@m2community.co.kr Publishing company ⟫ E-mail: ka72sus@smileml.com
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