Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
Evgeny Sidorov, Dharambir K. Sanghera, Jairam K. P. Vanamala
J Stroke. 2019;21(1):31-41.   Published online 2019 Jan 31     DOI: https://doi.org/10.5853/jos.2018.03454
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Frederic Mármol, Juan Sanchez, Albert Martínez-Pinteño
Prostaglandins, Leukotrienes and Essential Fatty Acids.2021; 165: 102237.     CrossRef
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Yunjie Wang, Xin Guan, Cheng-Long Gao, Wenchen Ruan, Shunyi Zhao, Guoyin Kai, Fei Li, Tao Pang
Pharmacological Research.2021; 169: 105640.     CrossRef
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Tilda Herrgårdh, Vince I. Madai, John D. Kelleher, Rasmus Magnusson, Mika Gustafsson, Lili Milani, Peter Gennemark, Gunnar Cedersund
NeuroImage: Clinical.2021; 31: 102694.     CrossRef
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Shuai Zhang, Jing Wang, Mei Jie Qu, Kun Wang, Ai Jun Ma, Xu Dong Pan, Xiao Yan Zhu
Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
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Frontiers in Neurology.2021;[Epub]     CrossRef
Metabolomic Profiles of Men and Women Ischemic Stroke Patients
Nicolas Poupore, Renee Chosed, Sergio Arce, Robert Rainer, Richard L. Goodwin, Thomas I. Nathaniel
Diagnostics.2021; 11(10): 1786.     CrossRef
Relationship of Alberta Stroke Program Early CT Score (ASPECTS) with the outcome of ischemic stroke and the neurocognitive stroke biomarkers
Ahmed Esmael, Mohammed Elsherief, Ahmed Abdel Khalek Abdel Razek, Nehal Tharwat Mohammed El-Sayed, Mohammed Abd Elsalam, Mohamed E. Flifel, Saad Shawki
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub]     CrossRef
Global metabolomics analysis of serum from humans at risk of thrombotic stroke
Adnan Khan, Mal-Soon Shin, Sun Ha Jee, Youngja H. Park
The Analyst.2020; 145(5): 1695.     CrossRef
Potential Metabolite Biomarkers for Acute Versus Chronic Stage of Ischemic Stroke: A Pilot Study
Evgeny Sidorov, Cynthia Bejar, Chao Xu, Bappaditya Ray, Lavanya Reddivari, Juliane Chainakul, Jairam K.P. Vanamala, Dharambir K. Sanghera
Journal of Stroke and Cerebrovascular Diseases.2020; 29(4): 104618.     CrossRef
Role of vinpocetine in ischemic stroke and poststroke outcomes: A critical review
HayderM Al-Kuraishy, AliI Al-Gareeb, MarwaThaier Naji, Farah Al-Mamorry
Brain Circulation.2020; 6(1): 1.     CrossRef
Serum metabolomic profiles reveal the impact of BuZangTongLuo formula on metabolic pathways in diabetic mice with hindlimb ischemia
Junping Zheng, Yanlei Guo, Baifei Hu, Lin Zhu, Yong Yang, Shengrong Li, Na Li, Hongtao Liu
Journal of Ethnopharmacology.2020; 258: 112928.     CrossRef
Metabolome Changes in Cerebral Ischemia
Tae Hwan Shin, Da Yeon Lee, Shaherin Basith, Balachandran Manavalan, Man Jeong Paik, Igor Rybinnik, M. Maral Mouradian, Jung Hwan Ahn, Gwang Lee
Cells.2020; 9(7): 1630.     CrossRef
Plasma metabolomic fingerprint of advanced cirrhosis stages among HIV/HCV‐coinfected and HCV‐monoinfected patients
Sergio Salgüero, David Rojo, Juan Berenguer, Juan González‐García, Amanda Fernández‐Rodríguez, Oscar Brochado‐Kith, Cristina Díez, Victor Hontañon, Ana Virseda‐Berdices, Javier Martínez, Luis Ibañez‐Samaniego, Elba Llop‐Herrera, Coral Barbas, Salvador Res
Liver International.2020; 40(9): 2215.     CrossRef
Circulating Metabolites as Potential Biomarkers for Neurological Disorders—Metabolites in Neurological Disorders
Amanda Donatti, Amanda M. Canto, Alexandre B. Godoi, Douglas C. da Rosa, Iscia Lopes-Cendes
Metabolites.2020; 10(10): 389.     CrossRef
NMR Plasma Metabolomics Study of Patients Overcoming Acute Myocardial Infarction: in the First 12 h After Onset of Chest Pain With Statistical Discrimination Towards Metabolomic Biomarkers
M PETRAS, D KALENSKA, M SAMOS, T BOLEK, M SARLINOVA, P RACAY, E HALASOVA, O STRBAK, J STASKO, L MUSAK, M SKORVANOVA, E BARANOVICOVA
Physiological Research.2020; : 823.     CrossRef
Prediction of Functional Outcome in Patients with Acute Stroke by Measuring tRNA Derivatives
Tomohisa Ishida, Takashi Inoue, Kuniyasu Niizuma, Natsumi Konno, Chitose Suzuki, Tomoo Inoue, Masayuki Ezura, Hiroshi Uenohara, Takaaki Abe, Teiji Tominaga
Cerebrovascular Diseases.2020; 49(6): 639.     CrossRef
Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide
Hyo Suk Nam
Journal of Stroke.2019; 21(2): 151.     CrossRef
Discovery of a New Biomarker Pattern for Differential Diagnosis of Acute Ischemic Stroke Using Targeted Metabolomics
Ruitan Sun, Yan Li, Ming Cai, Yunfeng Cao, Xiangyu Piao
Frontiers in Neurology.2019;[Epub]     CrossRef
Investigating the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat Using Metabolomics and Network Pharmacology
Yang Wang, Wenjun Guo, Yue Liu, Jifeng Wang, Meiling Fan, Hongyu Zhao, Shengxu Xie, Yajuan Xu
Metabolites.2019; 9(10): 240.     CrossRef