Dear sir
Intracranial dural carotid cavernous fistulas account for 10 to 15% of all intracranial arteriovenous malformations.
Depending on the amount and direction of venous drainage from the cavernous sinus, symptoms may include distended orbit, periorbital veins, and oculomotor, trochlear, and abducens nerve palsy.
A 41-year-old female visited our clinic with headache and vertical diplopia. The headache was pulsatile, located in the right orbito-temporal region, and had persisted for a month. Other than bilateral myopia, the patient's medical history revealed no trauma, hypertension, diabetes, or other medical problems such as connective tissue disease. On admission, her vital signs were stable. Chest X-ray and laboratory findings were normal. Neurological examination revealed vertical diplopia aggravated by upward gaze. When her head was tilted to the right side, the right eye showed hypotropia and vertical diplopia was aggravated. Thus, we confirmed the right superior rectus palsy; no other abnormalities were observed. Visual acuities and fields, pupil size and reactivity, and ophthalmoscopic findings were all normal. After a full examination for extraocular movement, right partial third cranial nerve palsy was suspected. The brain MRI revealed a carotid cavernous fistula (
We first performed a transvenous intervention to the right cavernous sinus using coil embolization on the patient's third day in hospital. The transvenous embolization was performed under local anesthesia via the ipsilateral jugular vein; the vein was punctured and a sheath introduced. A catheter was easily navigated through the inferior petrosal sinus to the cavernous sinus. However, the moment the coil was placed in the anterior chamber of the cavernous sinus the patient complained of severe headache and the procedure was stopped. Immediately after the first partial embolization, right infranuclear facial palsy and left side mixed clockwise torsional nystagmus at a neutral position developed. The brain MRI was normal. Despite the partial embolization, no significant change in the drainage of the dural fistula was observed (
In the second transarterial intervention on the sixth hospital day, arterial glue (20% n-butyl cyanoacrylate, 0.8 mL) was injected into the middle meningeal artery. Injection into the internal maxillary artery was also attempted, but it was aborted because of arterial spasm. Eventually fistular flow as revealed by external carotid angiography was reduced (
The patient's diplopia, nystagmus, and facial palsy gradually declined and resolved completely over two months. Subsequent angiography five months after embolization did not reveal any remnant of thedural carotid cavernous fistula (
Symptoms of dural carotid cavernous fistula include proptosis, elevated intraocular pressure, pulsatile bruits, and less commonly, ophthalmoplegia, facial palsy, and facial pain. In the present case, facial palsy and nystagmus developed
The classification of dural carotid cavernous fistulas by Barrow et al. involves four angiographic types, one direct (type A) and three dural (types B, C, and D).
The first intervention was not completed due to severe headache and the patient presented with facial nerve palsy and nystagmus shortly after transvenous embolization. We cannot fully account for the complications, but it is known that pressure palsy can occur because of slight venous engorgement around the internal auditory meatus connected to the inferior petrosal sinus,
The authors have no financial conflicts of interest.
T2-weighted MRI (A) shows increased signal voids around right cavernous sinus and MR angiography (B) shows dural fistula flow from internal and external carotid arteries. Pre-embolization angiograms (C, D) shows fistula flow via the internal carotid artery and the external carotid artery. The main flow drains to the internal jugular vein through the inferior petrosal sinus. Angiogram after the first transvenous embolization (E, F) shows insertion of the coil (arrowhead) into the cavernous sinus. After the second transarterial embolization (G, H), fistula flow via the middle meningeal artery (arrow) has decreased, and flow through the internal maxillary artery (arrowhead) has ceased due to vascular spasm. After 5 months, the dural carotid cavernous fistula has regressed (I, J) and there is no remnant aberrant flow.