Introduction
According to the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD 2010), stroke is the second most common cause of death [1] and the third most common cause of disability-adjusted life years (DALYs) [2] worldwide. In Korea, for a long time, stroke was the second leading cause of death after cancer [1]. However, since 2012, stroke lost its second rank to heart disease. According to the annual report on the Cause of Death Statistics by Statistics Korea, 45.8 subjects per 100,000 died of cerebrovascular disease but 58.2 subjects per 100,000 died of heart disease in 2016 [3].
Despite this great burden of stroke to our society, Republic of Korea has been classified as a country with no data on stroke incidence [4], although a recent attempt to summarize nationally representative data on stroke by the Korean Stroke Society and the Clinical Research Center for Stroke seemed to be successful [5-8]. However, these reports were based on published data mostly and had limitations related to representativeness and comprehensiveness.
The Epidemiologic Research Council of the Korean Stroke Society was established in 2015. Its mission comprises regular publication of statistical reports on stroke epidemiology of Korea. In early 2016, the Council received the approval of the executive committee of the Korean Stroke Society to launch the “Stroke Statistics in Korea” project, aimed at writing a report on stroke epidemiology in Korea. The report consists of five parts: (1) general statistics, including incidence, prevalence, and mortality; (2) prevalence of behavioral and vascular risk factors in general and stroke populations; (3) stroke characteristics, including stroke subtypes, stroke severity, lesion locations, and involved vascular territories; (4) the pre-hospital system, hospital management, and secondary prevention; and (5) quality of stroke care, costs, and outcomes. This report (1) provides a contemporary, comprehensive, and representative report on stroke epidemiology in Korea; (2) gives reliable resources to guide clinicians and investigators in their research; (3) helps healthcare policy makers to develop and implement healthcare plans; and (4) contributes to achieving the Vision 2020 goal of the Korean Stroke Society to reduce stroke incidence and disability by 10% within 10 years. The work group comprises a total of 40 writing group members and 11 central statistical supporting team members.
This executive summary contains key statistics of Stroke Statistics in Korea 2018. The full version of the report is available online at http://www.stroke.or.kr/bbs/?code=epidemic1 [9].
Methods
To write a report on stroke epidemiology in Korea, we analyzed the most up-to-date available databases, rather than performing a systematic review of existing evidence. For the details of the databases used in this report, see Table 1-1 in Stroke Statistics in Korea 2018 [9]. Most of the findings were obtained from direct analysis of these databases by the statistical supporting team.
To obtain data about the general population in Korea, the Korea National Health and Nutrition Examination Survey (KNHANES) database of the Korea Centers for Disease Control and Prevention (KCDC), the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database, and the Cause of Death Statistics of Statistics Korea were used. The KNHANES is a nationwide cross-sectional survey conducted every year by KCDC [10]. Each survey includes a new sample of about 10,000 individuals from non-institutionalized Korean citizens who are representative of the population. It comprises a health interview, health examination, and nutrition survey.
The NHIS-NSC database is a population-based cohort established by the NHIS. This cohort was constructed to provide representative information on Korean citizens’ utilization of health services to the public and related researchers [11]. In this cohort, a total of 1,025,340 subjects (2.2% of the entire eligible population) was randomly sampled from the nationwide Korean health insurance claim database in 2002, and followed up to 2013. This database contains information on socioeconomic status, provided treatments with diagnosis codes and details of prescriptions, and health checkup results.
Regarding stroke population in Korea, the Clinical Research Collaboration for Stroke in Korea (CRCS-K) database, the Acute Stroke Quality Assessment Program (ASQAP) database, and the NHIS-CRCS-K matching database were used. The CRCS-K database is a multicenter prospective registry of stroke patients who were admitted to 16 stroke centers in Korea [7,8]. Data fields of the registry cover demographics, risk factors, stroke characteristics including etiology work-ups and laboratory tests, acute stroke managements, secondary stroke prevention and outcomes.
The ASQAP is a national audit program that was conducted by the Health Insurance Review & Assessment Service (HIRA) for the assessment of the quality of stroke care in acute care hospitals in Korea. The ASQAP database contains information on both participating institutions and patients with acute stroke who were admitted to the participating hospitals within 7 days of onset via an emergency room.
The NHIS-CRCS-K matching database is a database constructed through linkage between the NHIS claim database and the CRCS-K database. Using this linked database, we could analyze the information, which is usually not collected in clinical stroke registers, on inpatient and outpatient care (diagnosis codes, length of stay, treatments and their costs, and services received), prescriptions (drug codes, days prescribed, and daily dosage), and institutions (types of institutions, human resources, and equipment). Matching in the NHIS-CRCS-K matching database was only performed for patients who were registered into the CRCS-K and agreed with providing their information for this purpose before the revision of the act on the protection of personal information in 2015.
In case a direct approach to nationally representative data was not available, the literature was reviewed systematically.
This study was performed in accordance with the Declaration of Helsinki and its Institutional Review Board approval was exempted by the Institutional Review Board of the Seoul National University Bundang Hospital of Korea (No. X-1609-364-901) mostly because it used anonymous databases open to the public.
General statistics
Based on the 2006 report of the KCDC, the estimated crude and age- and sex-standardized incidence of stroke was 216 and 232 per 100,000 person-years, respectively, in 2004 (Table 1) [5,12]. Standardization was performed based on the 2005 Population and Housing Census of Korea [13]. About 105,000 Korean people are presumed to experience a new stroke each year [5]. When we estimated the stroke incidence using the NHIS-NSC database, the age-standardized incidence rate of first-ever stroke was 92.2 per 100,000 person-years in 2013 (Figure 1). A total of 46,495 people was assumed to have a new diagnosis of stroke (I60-I64) in their lives.
The discrepancy of incidence between 2004 and 2013 implicates two possibilities about secular trends of stroke incidence in Korea: (1) a true decreasing tendency and (2) differences in methods of estimating stroke incidence. When considering the decreasing trends in both stroke mortality in Korea from 2006 to 2015 (for the detailed value, see Supplemental Table 3-1 in Stroke Statistics in Korea 2018 [9]) and stroke incidence in high-income countries from 1990 to 2010 [14], stroke incidence may have decreased from 2004 to 2013. However, another recent study by the KCDC reported that the crude and age-standardized stroke incidences were about 241 and 208 per 100,000 person-years, respectively, in 2014, which were similar to those in 2004, although the latter is limited by lack of validation [15]. Furthermore, stroke incidence in other East-Asian countries was approximately 300 per 100,000 person-years in 2010 to 2014 [16]. Regarding methodological differences, several reasons could be assumed. First, stroke incidence was confirmed only by principal diagnosis codes in the 2013’s estimation and recurrent or ceased stroke cases were excluded. Second, the sampling methods and rates are different; 2.2% of the eligible population was sampled based on the claim database and the attack rates among them were used to estimate the incidence in the entire population in the 2013’s estimation, while 3.0% of patients hospitalized with diagnosis codes of stroke and 8.4% of hospitals were sampled and used to calculate the incidence in the 2004’s estimation. Third, the specific diagnostic algorithm was developed and validated in the 2004’s estimation but not in the 2013’s. In addition to these methodological considerations, the recent KCDC report [15] and the stroke incidence data from other Asian countries [16] strongly support that the crude incidence of 216 per 100,000 person-years in the 2006’s KCDC report is more representative of the actual incidence.
The crude and age-adjusted prevalence (standardized according to the 2005 Population and Housing Census of Korea) [13] of stroke was estimated as 1.71% and 1.37%, respectively, in Korean adults aged ≥19 years in 2014 based on the KNHANES database (Table 1). A total of 692,259 patients were diagnosed as having stroke by physicians [9]. In the same year, with the same definition of stroke, stroke prevalence was 2.7% in adults aged ≥20 years in the United States (US) [17], and the difference between Korea and the US might be attributed, at least partly, to the difference in the standard population (2005 vs. 2014). In the NHIS-NSC database, the crude prevalence rate was 2.57% in Korean adults aged ≥20 years in 2013 (for the details, see Figure 2-2 in Stroke Statistics in Korea 2018 [9]). Stroke was defined, when estimating stroke prevalence using the NHIS-NSC database, as new assignment of principal diagnosis codes of I60 to I64 accompanied by a claim of brain computed tomography (CT) and/or magnetic resonance imaging (MRI). When considering the limitation of the NHIS-NSC database as claim data for reimbursement, the true prevalence lies near the figure estimated using the KNHANES database.
In the GBD study 2010, in which the World Health Organization (WHO) World Standard Population used in the latest United Nations (UN) assessment for 1998 served as a reference [18], the absolute number of prevalent stroke cases in Korea was 379,763 in 2010 [14]. When applying the age- and sex-specific stroke prevalence obtained from the KNHANES to the WHO World Standard Population, the estimated number of prevalent stroke cases in Korea is 451,000, slightly higher than the provided figure in the GBD study 2010.
In subgroup analysis using the KNHANES database, the prevalence of stroke increased with age (Table 1). Across all age groups, the prevalence was higher in men than women (see Figure 2-2 in Stroke Statistics in Korea 2018 [9] for details). Stroke prevalence in adults aged ≥50 years did not show any specific secular trends between 1998 and 2014 (Figure 2). The observed variation may be explained by the limitation of stroke diagnosis in KNHANES; stroke prevalence was obtained by one simple question, “Have you ever been diagnosed with stroke by a doctor?” The steady pattern in our study was not different from that in the US [17]. However, as the elderly population increases, the crude number of prevalent stroke cases also increases rapidly [9].
Regarding stroke subtypes, the incidence is highest for ischemic stroke, followed by intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) (Figure 1). Standardized incidence rates of stroke showed a decreasing tendency between 2007 and 2013, with the exception of 2011. A similar secular trend was observed for ischemic stroke. In case of hemorrhagic stroke (I60-I62), a decrease was not evident. The sharp increase of stroke incidence in 2011 might be attributed to the increase of claims with stroke diagnosis codes related to worries about curtailment according to expansion of reimbursement for brain MRI in the same year.
The age-standardized stroke mortality was 29.6 per 100,000 population in 2015 (Table 1). Standardization was performed using the age structure of general population in the 2005 Population and Housing Census of Korea [13]. On average, one person died because of stroke every 35 minutes in Korea. According the recent statistical report from the American Heart Association (AHA), the age-adjusted stroke mortality in the US was 37.6 per 100,000 in 2015 [17,19]. The GBD study also reported higher values of stroke mortality (60.54, 104.98, and 88.41 per 100,000 in high-income, low-income countries, and globally, respectively) [14]. The causes of the lower mortality than expected in Korea should be explored in future research.
Along with the global trends, stroke mortality is declining (Figure 3) [14]. From 2006 to 2015, the age-standardized stroke mortality decreased from 58.9 to 29.6 per 100,000 population (Figure 3). The actual number of stroke deaths also declined by 18.6% (see Supplemental Table 3-1 of Stroke Statistics in Korea 2018 [9] for details). In the US, from 2005 to 2015, the agestandardized stroke mortality decreased by 21.7% and the actual number of stroke deaths declined by 2.3% [17].
Stroke mortality steeply increased with age, particularly after age 70 (Table 1). In all age groups, men showed higher mortality than women (see Table 3-1 of Stroke Statistics in Korea 2018 [9] for details). Regional disparities in age-standardized stroke mortality are observed, with maximum 1.5-fold differences among regions in 2015 (Figure 4). Regional disparities are also found in the US, and are known as the “stroke belt.” [17,20,21] The overall stroke mortality is approximately 30% higher in the stroke belt than in the rest of the nation [22], which has been associated with lower socioeconomic status, a greater proportion of black residents, higher prevalence of chronic disease, and underutilization of healthcare services [17,23]. Patterns of regional disparities in stroke mortality seem to be similar to those in hypertension prevalence in Korea (Figure 5). Considering the proven effect of risk-factor control, especially hypertension control [24], for preventing stroke deaths, the observed association between regional disparities in stroke mortality and hypertension prevalence gives us a guidance for resolving such disparities.
Risk factors
High-risk alcohol intake, hypertension, diabetes, and atrial fibrillation were more prevalent in the stroke population than in the general population (Table 2). In the general population, smoking was the most prevalent risk factor, followed by hypertension, high-risk alcohol intake, diabetes, hypercholesterolemia, obesity, and atrial fibrillation. In the stroke population, hypertension was most common, followed by diabetes, high-risk alcohol intake, smoking, atrial fibrillation, hypercholesterolemia, and obesity.
The prevalence of current smoking is much higher in Korea than the US (24% vs. 15% in all, 43% vs. 17% in men, and 6% vs. 14% in women) [17]. Smoking prevalence in men decreased by a third from 1998 to 2014 (Figure 6A). Smoking prevalence in women, however, did not decrease. Regarding high-risk alcohol intake, its prevalence was three times higher in men than women and was higher in both sexes in Korea compared to global data (21% vs. 16% in men and 7% vs. 4% in women) (Table 2) [25]. Over the past 10 years, the prevalence of high-risk alcohol intake did not change in men, but has increased gradually in women (Figure 6B).
The prevalence of obesity defined as body mass index (BMI)≥30 is increasing slightly in general and stroke population (see Table 7-1 and Table 7-7 of Stroke Statistics in Korea 2018 [9] for details). This increase is mostly attributable to the increase in those aged 19 to 54 years, and similar findings were observed in the US (Figure 7 in this article and Table 7-2 of Stroke Statistics in Korea 2018 [9]) [26].
The prevalence of hypertension in 2007 did not differ from that in 2014 in the general and stroke populations (for details, see Figure 8-2 and 8-5 in Stroke Statistics in Korea 2018 [9]). However, during this period, the prevalence in the general population increased slightly from 2007 to 2009, then returned to the level of 2007 in 2014. The crude number of patients diagnosed with hypertension tripled from 2002 to 2016 in Korea [27]. The prevalence of diabetes mellitus increased slightly between 2007 and 2014: 7.7% to 8.0% in the general population and 30.7% to 32.4% in the stroke population (for details, see Figure 9-2 and 9-5 in Stroke Statistics in Korea 2018 [9]). The prevalence of diabetes among Korean adults is expected to rise up to 11.4% in 2030 with aging of the population [28]. The prevalence of hypercholesterolemia (≥240 mg/dL) was 7.8% in the general population and 7.2% in patients with acute ischemic stroke (for details, see Table 10-1 and 10-4 in Stroke Statistics in Korea 2018 [9]). As in the US and Europe, the prevalence of atrial fibrillation is increasing gradually, and this tendency is more marked in the stroke population than in the general population (for details, see Table 11-1 and Figure 11-1 in Stroke Statistics in Korea 2018 [9]) [17,29,30].
Population-attributable risk was estimated for individual risk factors according to age groups and sex (Table 3). In young and middle-aged men, smoking is the most important risk factor, and in young and middle-aged women, hypertension is most important. In the elderly, hypertension is most important in both sexes. These findings are similar to those of the previous study using the CRCS-K database between 2008 and 2010 and the 4th KNHANES (2008 to 2010), with the exception of the lower contribution of hypertension in young women (14.3% vs. 5.4%) [31]. The prevalence of atrial fibrillation in the stroke population is increasing with age, and more prominently so in women (Figure 8), which may reflect a greater contribution of atrial fibrillation to stroke incidence with aging in women than men [32,33].
Stroke characteristics
According to the nationwide data from the ASQAP, ischemic stroke is the most common type of stroke, accounting for about 76% of stroke admissions, followed by ICH and SAH (Figure 9). This proportion of ischemic stroke is slightly lower than the 80% of the US [34], but similar to that of European countries [35]. Regarding ischemic stroke subtypes, according to the CRCS-K data, about 37% of patients with ischemic stroke had large artery atherosclerosis (LAA), followed by cardioembolism (22%) and small vessel occlusion (SVO, 18%). Classification of ischemic stroke subtypes were based on the MRI-based diagnostic algorithm for acute ischemic stroke subtype classification (MAGIC), a modification of The Trial of Org 10172 in Acute Stroke Treatment classification [36]. Analysis of secular trends in ischemic stroke subtypes showed a slight decrease of LAA, an increase of cardioembolism, and a decrease of SVO between 2008 and 2015 (Figure 10). These trends were not much different from those reported in another study from Korea between 2002 and 2010 [37] and in a study from Canada between 2002 and 2012 [38].
Stroke severity was mild in a majority of patients with stroke according to the ASQAP database (Figure 11), which was similar to previous reports from the US [39,40]. About half of ischemic and hemorrhagic stroke cases had NIHSS of four or lower (see Supplemental Table 17-1 and 17-2 of Stroke Statistics in Korea 2018 [9] for details). Severe neurological deficits at symptom onset (NIHSS scores of 25 or higher) were more common in hemorrhagic stroke than in ischemic stroke (13.9% vs. 1.5%).
Regarding the anatomical location of ischemic stroke lesions, the cortex was the most common location; about half of the patients with ischemic stroke had cortical lesions. Other common locations were the corona radiata, putamen-internal capsule, pons, cerebellum, and thalamus, in order (see Table 18-1 and 18-3 of Stroke Statistics in Korea 2018 [9] for details). Older (≥75 years) patients with ischemic stroke were more likely to have ischemic lesions involving the cortex and corona radiata, whereas younger (<55 years) patients were more likely to have medullary and cerebellar lesions. More than half (57.3%) of cases with acute ischemic stroke had lesions in a middle cerebral artery territory.
Acute management and secondary prevention
Approximately 42% of patients with stroke arrive to the hospital within 3 hours of symptom onset, and 55% within 6 hours of onset (Table 4 and Figure 12). Compared with the US, the median time from symptom onset to arrival is longer in Korea, especially for ischemic stroke (2.3 vs. 4.6 hours for all strokes and 2.8 vs. 6.2 hours for ischemic stroke) [41]. Unfortunately, secular trends of onset-to-arrival time did not improve from 2008 to 2014. Slightly more than half of patients (56%) used an ambulance to reach an emergency room, a rate lower than that of other Organisation for Economic Co-operation and Development (OECD) countries (58% to 79%) [41-44], and the ambulance utilization rates varied markedly by region (Figure 13). Greater involvement of emergency medication systems (EMS) into stroke systems of care, such as advance notification to the receiving hospitals by EMS, reduces treatment delay and increases the likelihood of being treated with reperfusion therapy [45-47].
Regarding reperfusion therapy, 1/10 and 1/30 acute ischemic stroke patients received intravenous thrombolysis (IVT) and endovascular treatment (EVT), respectively, during 2013 and 2014 (Table 4). The IVT rate in Korea is higher than that in the US (7.0% in 2010 to 2011) [48] and most European countries, and is similar to or slightly lower than that in the United Kingdom (UK), Germany, Netherlands, Finland, and Austria [49,50]. The EVT rate is not different from that of the US (3.3% in 2016) [51]. When looking into the secular trends, the proportions of patients receiving IVT only, EVT only, and both IVT and EVT increased between 2008 and 2014 (for details, see Figure 20-2 in Stroke Statistics in Korea 2018 [9]). IVT rates varied by region; the highest rate was 15% in Gwangju but less than 8% in Gyeongbuk, Jeonbuk, and Daejeon (Figure 14). Efforts for reducing such disparities are needed at societal and governmental levels.
The Korean Stroke Society proposed the standards for stroke unit care in 2007, and started a stroke unit certification program in 2012. The number of hospitals providing stroke unit care increased from 25 (13.0% of acute care hospitals) in 2008 to 65 (34.4%) in 2014 (Figure 15). However, the reimbursement of stroke unit care by NHIS began in the late 2017, and the reimbursement price is still very low. This is hampering the nationwide expansion of stroke unit care, and the distribution of acute care hospitals providing stroke unit care inclines toward big cities (Figure 16). Only about one-third of patients with stroke received stroke unit care in 2014. This proportion is similar to that across Europe (30%), higher than that in Canada (23%), but much lower than that in Australia (67%) and other European countries (Germany, 77%; UK, 83%; Sweden, 88%) [50,52,53]. In terms of case fatality, patients admitted to hospitals providing stroke unit care showed lower in-hospital death as well as 1-month and 1-year case fatality (Table 5). Therefore, further efforts for dissemination of stroke unit care, such as raising the reimbursement price and introducing stroke unit care into a major component of the hospital accreditation program, are urgent at governmental and societal levels.
The frequency of patients with ischemic stroke or transient ischemic attack who received antithrombotic therapy at admission was about 92 % (antiplatelet in 85% and anticoagulant in 12%; overlap was allowed) according to the CRCS-K database (Figure 17). This frequency of 92% was similar to that of the US (95.1%) [41] and Taiwan (94.8%) [54]. Regarding antiplatelet therapy, aspirin monotherapy was most common at admission (58.9%) and dual or multiple antiplatelet therapy was most common at discharge (46.5%). Regarding anticoagulant therapy, warfarin was the most common medication at admission and discharge (59.8% and 97.1%, respectively) until 2015.
For assessment of adherence to secondary preventive medication, the proportion of days covered (PDC) was calculated at 1 year after index stroke. One-year PDC was obtained using the NHIS-CRCS matching database by dividing the number of prescription days by 365 days. PDC of medications for dyslipidemia, diabetes, and hypertension was assessed per medical condition. Patients who deceased at the point of 1 year after discharge or whose mortality was unknown were excluded from the analysis (15.1%). However, the proportion of patients who were lost to follow-up was minimized by comprehensive assessment of claim data, regardless of the hospital. PDCs for dyslipidemia and diabetes were suboptimal (Table 4). However, PDC for hypertension was relatively high. Compared to a previous study from the US [55], using the AHA Get With The Guidelines-Stroke database, adherence was much lower in Korea (91% vs. 75% for lipid-lowering drugs, 91% vs. 74% for antidiabetic drugs, and 92% vs. 82% for antihypertensive drugs). Furthermore, the PDCs in this report might be overestimated because the NHIS-CRCS matching database was originated from patients with stroke who were admitted to university hospitals or regional stroke centers, which were motivated to improve the quality of stroke care.
Quality of care and outcome
Regarding the quality of care, all quality indicators in acute ischemic stroke improved continuously from 2008 to 2014 (Table 6), and this improvement could be attributed to various efforts, including the ASQAP by HIRA, stroke unit certification by the Korean Stroke Society, and establishment of regional comprehensive stroke centers by Ministry of Health and Welfare [56]. Regarding the outcomes, 1-month case fatality was 9.4% for all strokes and 5.2% for ischemic stroke in Korea (Table 7), which were lower than those of other developed countries; the 28-day case fatality was 17% to 30% for all strokes and 13% to 23% for ischemic stroke in high-income countries in 2000 to 2008 [4]. According to the OECD Health Statistics 2018, the 30-day case fatality for ischemic stroke was the second lowest in Korea (4.1%), following Japan (3.1%) among OECD countries [57]. One-year case fatality was 18.6% for all strokes and 14.6% for ischemic stroke in Korea, which were comparable to those of Denmark [58] but lower than those of England [59].
According to the NHIS-CRCS matching database, fracture occurs commonly after ischemic stroke. The cumulative incidence at 1 year was 1.1% for hip fracture, 2.0% for spine fracture, and 4.7% for a composite of fractures (Table 8). The incidence of fractures increases with age and lower or higher BMI. Bleeding also occurs frequently after ischemic stroke. The cumulative incidence at 1 year was 8.9% for a composite of bleedings and 7.1% for gastrointestinal bleeding requiring transfusion of two or more packs of red blood cells (Table 8). Incidence of bleeding increases with age, lower BMI, lower kidney function, and dependency at discharge (modified Rankin Scale score 4-5).
According to the Korean Burden of Disease study [60], cerebrovascular disease including both ischemic and hemorrhagic stroke, was the second leading cause of DALYs following diabetes mellitus in 2002. In 2012, stroke took the third place following diabetes mellitus and low back pain (Table 28-2 of Stroke Statistics in Korea 2018 [9] for details) [61]. On the other hand, ischemic heart disease took the 5th place both in 2002 and 2012. According to the GBD study 2010 [2], ischemic heart disease was the leading cause of DALYs worldwide, followed by lower respiratory infections and stroke. Stroke was the fifth cause in 1990 and the rate increased by 19% in 2010.
In 2015, the total direct costs of stroke were ₩1,684 billion (KRW), of which ₩1,118 billion were for ischemic stroke and ₩540 billion for hemorrhagic stroke (₩1,200 is approximately $1 [USD]) (Figure 18). Compared to 2011, the direct costs for all stroke, ischemic stroke, and hemorrhagic stroke increased by 29.6%, 36.2%, and 27.9%, respectively, in 2015. Costs of ischemic stroke are increasing to a greater extent than those of hemorrhagic stroke and comprise two thirds of total stroke cost. However, average admission cost per episode was about two times higher for hemorrhagic stroke than for ischemic stroke (see Figure 27-2 and Supplemental Table 27-2 of Stroke Statistics in Korea 2018 [9] for details) [20].
Conclusions
Stroke is a great socioeconomic burden to our society because of its high prevalence, incidence, and related morbidities, even if mortality is declining. Modifiable risk factors are highly prevalent and differ according to age and sex. There is opportunity for improving acute stroke management in Korea, especially through reorganizing pre-hospital systems, expanding stroke unit care, and reducing regional disparities in pre-hospital and hospital care. We hope that this report will contribute to achieving these tasks.
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