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J Stroke > Volume 23(2); 2021 > Article
Olindo, Chausson, Signate, Mecharles, Hennequin, Saint-Vil, Edimonana-Kaptue, Jeannin, Landais, Cabre, Sibon, Smadja, and Joux: Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study


Background and Purpose

Carotid web (CaW) is an intimal variant of fibromuscular dysplasia responsible for ipsilateral cerebral ischemic events (CIE). Symptomatic CaW likely has a high risk of recurrent CIE, but no salient prospective data are available. We aimed to assess recurrence rate and its predictors after a first-ever CIE.


Consecutive Afro-Caribbean patients who had cryptogenic first-ever CIEs (ischemic stroke [IS] or transient ischemic attack [TIA]) associated with ipsilateral CaW were included in this multicenter observational cohort study. The follow-up (January 2008 to March 2019) focused on CIE recurrences. Kaplan-Meier method assessed rates of recurrences and Cox proportional hazards regression analyzed risk factors.


Ninety-two patients (79 first-ever ISs and 13 TIAs; mean age±standard deviation, 49.8±9.9 years; 52 [56.5%] women) were included. During a mean follow-up of 50.5±29.6 months, 19 (20.7%) patients experienced recurrent ipsilateral CIEs (16 ISs and three TIAs). Of 23 patients receiving surgery/stenting treatment, no recurrence occurred after the intervention (median follow-up, 39.8 months [interquartile range, 27.6 to 72.4]). Under medical treatment alone, the annual recurrent CIE rate was 6.9%, and the cumulative rate was 4.4% at 30-day, 10.8% at 1-year, 19.8% at 2-year, 23.2% at 3-year, and 27.3% at 5-year. Presence of silent cerebral infarctions was the only independent risk factor of CIE recurrences (hazard ratio, 6.99; 95% confidence interval, 2.4 to 20.4; P=0.004).


Under medical treatment alone, symptomatic CaW was associated with a high rate of recurrence that reached 27.3% at 5-year. Surgery/stenting seems to be efficient, and randomized control trials are required to confirm the benefit of these interventions.


Carotid web (CaW) is an intimal and non-circumferential variant of fibromuscular dysplasia located at the origin of the carotid bulb and characterized by a membrane-like lesion protruding into the artery lumen [1-3]. CaW is increasingly recognized as a potential etiology of cryptogenic ischemic stroke (CIS) and usually described in middle-age patients with a slight female prevalence [4-7]. Predominance of CaW in the black population has been suggested through case series [3,8], and a recent systematic literature review showed that African descendants accounted for the largest part (58.6%) of all reported symptomatic CaW cases [9]. The widely accepted mechanism of cerebral ischemic events (CIE) is an artery-to-artery embolism through blood stasis rostral to CaW, thrombus formation and clot fragmentation scattered by the blood flow [10]. Large ischemic strokes (ISs) are often observed and related to a high rate of vessel occlusion [11,12]. According to single case observations and small case series, symptomatic CaW seems to be associated with a high risk of CIE recurrences ranging from 25% to 71% despite anti-thrombotic therapies [3,11,13]. Although seldom reliable data is available regarding the risk of recurrence, a growing number of CaW patients have been treated with invasive treatment such as surgery or stenting [3,11].
The aim of the present study was to assess the long-term recurrence risk and its predictors in a large Afro-Caribbean cohort who experienced a first-ever CIE associated with an ipsilateral CaW. Clinical and imaging data of the cohort are also detailed.


Study and patients

In January 2008, this cohort study was implemented to prospectively enroll consecutive Afro-Caribbean patients who had symptomatic CaW admitted to two French Caribbean hospitals, Martinique and Guadeloupe. This study focused only on Afro-Caribbean patients because this ethnic group constitutes the overwhelming majority of the population in these areas and is particularly affected by CaW. The Afro-Caribbean origin was based on self-identification. The University hospital of Martinique was the coordinating center. In 2014, two additional French hospitals, Bordeaux and Corbeil-Essonnes, took part in the constitution of the cohort. Centers were selected according to the clinical experience of local physicians in CaW diagnosis. Patients were included between January 2008 and December 2016 and were followed-up until March 2019. The cohort was observational and each center applied their own therapeutic strategy including invasive preventive treatment such as surgery or stenting. Local ethic committees with the backing of Commission National de l’Informatique et des Libertés (CNIL), the French data protection authority, approved the study.
Patients were included without any age criteria. Symptomatic CaW was defined as CaW in the internal carotid artery, leading to CIE (IS or transient ischemic attack [TIA]) in the carotid territory ipsilateral to the CaW lesion. Patients or next of kin were systematically asked to participate in the cohort study that resulted in periodic consultations at the hospital and by phone call. At the enrollment, the investigators completed a data form that included demographic data, vascular risk factors, patient’s medical histories, admission clinical symptoms and the National Institutes of Health Stroke Scale (NIHSS) score, acute and secondary prevention treatments, infarction territory, diffusion-weighted imaging Alberta Stroke Program Early CT Score (DWI-ASPECTS) [14] in case of middle cerebral artery (MCA) territory infarction, presence of silent cerebral infarction (SCI), presence of artery occlusion and its location. Extra and intracranial arteries were systematically assessed on computed tomography angiography (CTA). SCI was defined as chronic cerebral infarction on imaging without a history of clinical stroke or TIA attributable to the lesion [15]. For the current study, only patients with first-ever CIE classified as cryptogenic were considered. Cryptogenic IS or TIA was determined after extensive standardized work-up that included intracranial and extracranial vascular imaging with CTA, transthoracic and transesophageal echocardiography, cardiac telemetry monitoring (>48 hours), continuous ambulatory electrocardiography (24 to 72 hours), extensive blood laboratory testing and cerebrospinal fluid analysis when indicated.

Outcome assessment

The primary outcome was recurrent CIE. Visit at the study sites with face-to-face assessment was performed at 3-month then every 12 months to identify CIE recurrence. For patients who had moved away from the study area, the evaluation was investigated via phone call. When the recurrent CIE was not managed in the investigator’s stroke units, the general practitioner was contacted, and the hospitalization report and imaging were analyzed to confirm and classify the event. Information on medical treatment at the time of recurrent CIE was collected. For each recurrent CIE, we determined the etiologic mechanism. Recurrent CIE included IS and TIA. IS was defined as a new focal neurological deficit lasting >24 hours or as an acute cerebral infarction on magnetic resonance imaging (MRI) or computed tomography (CT) consistent with the clinical symptoms [15]. TIA was defined as a new neurological deficit consistent with a transient focal brain dysfunction lasting <24 hours without any cerebral infarction on imaging. Fluctuations or worsening of the index stroke were not determined as recurrent CIE. Clinical worsening in relation with brain edema, hemorrhagic transformation of index IS, metabolic and systemic disturbance were not considered as recurrence.
The secondary outcome was the functional status assessed with the modified Rankin Scale (mRS) score 3 months after the first-ever CIE and at the end of follow-up. A favorable outcome was defined as mRS score ≤2.

Case ascertainment of carotid web

Diagnosis of CaW was performed on CTA that was chosen for its widespread availability, the ability of image reconstruction and the capacity to identify differential pathologies such as atherosclerosis or dissection. CTA is now considered as the method of choice for CaW diagnosis [6,16]. Carotid artery bulb was analyzed in the axial, coronal and sagittal plane of CTA using a maximal intensity projection reconstruction (Supplementary Figure 1). CTA patterns consistent with CaW were: (1) A linear defect that usually splits the arterial lumen on axial plane. (2) A regular and thin shelf-like intraluminal-filling defect usually arising from the posterior wall of the proximal carotid bulb. (3) The absence of atherosclerosis plaque features such as calcifications or irregularities of the lesion shape. Small protruding lesions [13] were not categorized as symptomatic CaW. The contralateral carotid bulb was examined and lesions of CaW were collected. Three investigators (S.O., A.S., and J..J.) systematically analyzed each suspected case and the diagnosis of symptomatic CaW was adjudicated by consensus. Carotid bulb stenosis resulting from CaW protrusion was measured according to the European Carotid Surgery Trial (ECST) method17 and was expressed as a percentage.

Statistical analysis

Categorical variables are presented as number (%), and continuous variables are expressed as mean±standard deviation (SD) or as median with interquartile range (IQR) if skewed. Categorical variables were compared with the chi-square test, and continuous variables were compared with Student’s t-test or Mann-Whitney’s U test.
The annual recurrent rate was calculated using event numbers and median follow-up time and represents the average number of CIE per 100 person-years. Kaplan-Meier curves were used to estimate the cumulative incidence of CIE or IS recurrence over time. End of follow-up was defined by the day of last visit assessment including patients who were lost to follow-up. Two analyses were performed: (1) for the whole follow-up period and (2) for the follow-up period under medical treatment alone: for patients who did not receive surgery or stenting, the whole follow-up period was considered; for patients treated with surgery or stenting, the period from the inclusion to the day before surgery or stenting was considered. We used Cox proportional hazards regression analysis to explore risk factors of CIE recurrence during the follow-up period for patients under medical treatment. A multivariable analysis including factors that had P-values of <0.05 in univariable analysis was also performed. Results were expressed as hazard ratio (HR) and 95% confidence interval (CI). Analyses were performed with StatView 5.0 (Informer Technologies Inc., Roseau Valley, Dominica) and Microsoft Excel software. The level of statistical significance for the P-value was set at less than 0.05.


Between 2008 January and December 2016, 105 Afro-Caribbean patients were included in our cohort. In the present study, after excluding 13 patients with recurrent CIEs, 92 patients with first-ever CIE were included. Among the 92 patients, 82 were recruited from Martinique, four from Guadeloupe, four from Corbeil-Essonnes, and two from Bordeaux. The median follow-up duration (inclusion to last visit) was 45.5 months (IQR, 32.4 to 68.4). On March 2019, four patients (4.3%) were lost to follow-up. The demographic, clinical, and imaging baseline data for the 92 symptomatic CaW patients are summarized in Table 1.

Clinical pattern and functional outcome of first-ever CIE associated with a CaW

The mean age at first-ever CIE was 49.3±9.7 years (range, 26 to 72) and 56.5% were females. Of the included patients, 25.0% were aged >55 years, and 56.5% did not have any vascular risk factors. The most common risk factors were high blood pressure (20.6%) and smoking (20.6%). Mean admission NIHSS score was 7.7±7.4 (range, 0 to 27), 51.1% experienced a TIA or a minor stroke (NIHSS <5), 32.6% had a moderate stroke (NIHSS, 5 to 15) and 16.3% suffered from a severe stroke (NIHSS >15). At 3 months, 23.9% of the included patients had an unfavorable outcome (10.8% had mRS 3, 8.7% mRS 4, 1.1% mRS 5, and 3.3% mRS 6). Vessel occlusion (95.4% vs. 42.8%, P<0.0001), IS as first-ever CIE (100% vs. 0%, P=0.03), high admission NIHSS (15±6 vs. 4.8±5.7, P<0.0001) and low admission DWI-ASPECTS (4.0±2.1 vs. 7.7±1.6, P<0.0001) were associated with 3-month unfavorable outcomes. At the final follow-up visit, 92.4% achieved a favorable outcome (mRS 0-2).

Imaging characteristics of first-ever CIE associated with a CaW

At inclusion, 13 patients experienced a TIA as first-ever CIE and two patients suffered from a central retina artery infarction without any recent lesion on admission MRI. Of the 92 patients included, 42 (45.7%) had superficial MCA territory infarction (the most frequent infarction pattern) as their first-ever CIEs, and 51 (55.4%) had large vessel or branch occlusion. In patients with MCA infarction, the mean DWI-ASPECTS score was 7.2±2.5 (range, 0 to 10) and 25.8% experienced a very large stroke (DWI-ASPECTS ≤5).
SCI ipsilateral to the index CIE were found in seven patients (7.6%) while one patient with bilateral CaW showed SCI contralateral to the index CIE. All SCIs were cortical or cortico-subcortical lesions.

Acute and long-term treatments

Thirty-three patients (35.9%) received intravenous thrombolysis, six (6.5%) were treated with mechanical thrombectomy and three (3.3%) underwent decompressive hemicraniectomy. At the end of follow-up, preventive therapy was as follow: antiplatelet treatment in 52 (56.5%) patients, oral anticoagulation treatment in 12 (13%), no specific preventive treatment in five (5.5%), carotid artery surgery in 21 (22.8%), and carotid artery stenting in two (2.2%). All patients treated with carotid surgery or stenting received long-term antithrombotic therapy with aspirin (n=21) or vitamin K antagonist (n=2) that was ongoing at the end of follow-up. Comparisons between the surgery/stenting group (n=23) and the medical treatment group (n=69) are summarized in Table 2. Compared to patients managed with medical therapy alone, patients who received surgery or stenting were younger at the time of first-ever CIE (45.9±9.7 years vs. 50.4±9.5 years, P=0.02), were more likely to have vessel occlusion (82.6% vs. 46.7%, P=0.005), and had more severe CaW stenosis (43%±13% vs. 34%±14%, P=0.002).

Characteristics of symptomatic CaW

In most patients (97%), CaW was located on the posterior and lateral wall of the carotid bulb. According to the ECST method, the mean symptomatic carotid bulb stenosis was 36%±14%. Of 21 surgically resected webs, 14 specimens underwent pathological examinations. The web lesion showed a thin translucent intraluminal diaphragm on macroscopic inspection and the histological examination revealed focal intimal hyperplasia that minimally involved the media layer. A contralateral asymptomatic CaW was diagnosed in 42 patients (46.5%). In these patients, the stenosis degree was less severe in the asymptomatic CaWs than in the symptomatic CaWs (30%±13% vs. 37%±15%, P=0.03).


Nineteen (20.7%) out of 92 patients experienced a recurrent CIE (16 ISs and three TIAs) during the follow-up period. Characteristics of patients with and without CIE recurrence are detailed and compared in Table 3. Male sex (68.4% vs. 37.0%, P=0.02) and presence of ipsilateral SCI (26.3% vs. 2.7%, P=0.003) were significantly associated with recurrences on univariable analysis.
All recurrences were ipsilateral to the first-ever CIE. At the time of recurrent CIE, 16 patients were taking antiplatelet monotherapy, two were on oral anticoagulant therapy, and one did not have any anti-thrombotic therapies. In 42 patients with bilateral CaWs, no CIE recurrence was associated with asymptomatic CaW. The median follow-up time of asymptomatic CaW (inclusion to last visit delay) was 44.8 months (IQR, 36.1 to 66).
In patients who received carotid surgery or stenting for symptomatic CaW, no recurrence occurred after the intervention. In these patients, the median interval from the first-ever CIE to surgery or stenting was 7.5 months (IQR, 4.6 to 12.5) and the median follow-up time after surgery or stenting was 39.8 months (IQR, 27.6 to 72.4). The median follow-up time of patients under medical treatment alone (for patients without surgery or stenting, the whole follow-up period was considered, and for patients who received surgery or stenting, the period from the inclusion to the day before surgery or stenting was considered as the follow-up duration of medical treatment alone) was 36 months (IQR, 11 to 58).
In all patients, the annual recurrent CIE rate was 5.4%/year. When we analyzed the recurrent CIE rate for the follow-up period under medical treatment alone, it was 6.9%/year. For the cumulative CIE rate during the follow-up under medical treatment alone, it was 4.4% at 30-day, 10.8% at 1-year, 19.8% at 2-year, 23.2% at 3-year, 27.3% at 5-year, and 63.6% at 10-year (Figure 1 and Supplementary Table 1). The cumulative CIE rates for the whole follow-up period and for subgroups according to sex and SCI presence are detailed in Supplementary Table 1. In multivariable Cox proportional regression analysis, the presence of SCI was the only independent risk factor of CIE recurrence (HR, 6.99; 95% CI, 2.4 to 20.4; P=0.004) (Table 4). A case of recurrent CIE is illustrated in Figure 2.


We report a large series of symptomatic CaW and provide prospective data regarding the recurrent rate of IS or TIA. Our main findings are: (1) Despite preventive antithrombotic treatment, symptomatic CaWs were associated with a high risk of CIE recurrences that reached 10.8% at 1-year, 19.8% at 2-year, and 27.3% at 5-year. (2) SCI ipsilateral to the symptomatic CaW was an independent risk factor of CIE recurrence (HR, 6.99; 95% CI, 2.4 to 20.4; P=0.004). (3) Surgery or stenting of CaW seems to be efficient as no recurrence was identified after the intervention with a median follow-up time of 39.8 months (IQR, 27.6 to 72.4). (4) Recurrent CIEs were exclusively associated with symptomatic CaW, and there was no recurrent CIE related to asymptomatic CaW.
Association between CaW and ipsilateral stroke recurrence has been described since the first case reports [1,18]. Three small case series showed that symptomatic CaW patients had a high risk of stroke recurrences ranging from 25% to 71.4% [3,11,13]. In accordance with our findings, recurrent strokes occurred under antiplatelet treatment. Whether the index stroke was a first-ever CIE was not clear in these studies. A recent systematic literature review found a 56% rate of recurrence among patients medically treated [19]. However, the analysis was performed on small series and single observations of interest and the recurrent rate may be overestimated. In our study, the curve for cumulative incidence of CIE is steepest in the first 2 years after the first-ever CIE. Subsequently, the ascent appears less steep between 2 and 5 years. Although CaW is still listed as a cause of CIS [20], we showed that the recurrent stroke or TIA risk with symptomatic CaW was much higher than those reported in young patients with usual CIS for whom the cumulative 5-year rate has been estimated at 8.2% [21]. In a recent randomized trial for patients with embolic stroke of undetermined source, the annual recurrent stroke rate under aspirin was 4.8% [22]. Patients medically treated for CIS associated with patent foramen ovale also had a lower recurrent risk estimated at 1.17% per year [23]. In our cohort, the 23 patients treated with carotid surgery or stenting were free of recurrence after a median follow-up of 39 months. Surgery has been proposed as invasive treatment option [3], and small series of carotid endarterectomy in symptomatic CaW have reported data for acceptable safety and efficacy after a median follow-up around 12 months [3,13,24-26]. Endovascular procedure has also been reported as safe [27], and a recent study [28] showed that the procedure performed in 24 symptomatic CaW patients was effective to prevent recurrence after a median clinical follow-up of 12 months. Although no randomized data are available, invasive treatment such as surgery or stenting seems now increasingly proposed as secondary preventive strategy [29]. In the present study, patients treated with surgery or stenting had a higher rate of vessel occlusion and a more severe stenosis related to CaW than medically treated patients. Physicians and patients may have been more convinced that CaW was responsible for CIE when the lesion was more prominent and associated with artery occlusion. No recurrence was recorded in the contralateral carotid territory even in patients with bilateral CaW. Our findings suggest that surgery or stenting is not recommended for asymptomatic CaW.
We found that the risk of CIE recurrences was 2.7 times higher in males compared to females. This result was not supported by other studies that usually reported no difference [30] in stroke recurrence between males and females or a slightly higher risk in females [31]. SCI ipsilateral to the first-ever CIE, was detected in 7.6% of our cohort and constituted a strong predictor of recurrence (HR, 8.4; 95% CI, 2.9 to 24; P<0.001). The presence of SCI might indicate a high embolic potential of the CaW lesion.
This study has several limitations. Although all cases showed classic imaging characteristics of CaW, the lesion was histologically proven in a minority of patients. The cohort study was implemented in the Caribbean area in 2008 and thereby focused only on Afro-Caribbean patients. Our findings should be interpreted with caution when applied to other ethnic groups. Recurrent CIEs were often reported by patients, which might underestimate the recurrent rate. A small number of patients had SCI (n=7) and the association with recurrent risk should be considered with caution. We obtained no data on adherence to antithrombotic therapies, particularly for long-term antiplatelet treatment. Secondary stroke prevention therapies other than antithrombotic therapy was not systemically captured and therapeutic strategies differed overtime and across the participating centers. Thus, the different efficiency for preventing recurrent stroke between medical treatment alone and invasive treatment should be interpreted with caution. However, the baseline characteristics of patients without and those with surgery or stenting were generally comparable. Given that patients who received surgery or stenting group had more severe CaW stenosis and more vessel occlusions, these patients might be at higher risk of recurrent CIE without the intervention. The strengths of this study are the prospective identification of CIE recurrences with a large cohort of symptomatic CaW and the long follow-up period. Additionally, symptomatic CaW is now increasingly treated with stenting or surgery and data on recurrence under medical treatment might be hardly available in the future.


This study provides key data on IS and TIA recurrences after a first-ever CIE associated with symptomatic CaW. Recurrent ISs or TIAs occurred in 19.8% at 2-year and 27.3% at 5-year despite antithrombotic treatment. SCI ipsilateral to symptomatic CaW was the only predictor of recurrences. Given the high recurrent risk under medical treatment alone, CaW should be systematically investigated in patients with CIS. In our cohort, invasive treatments such as surgery excision and endovascular stenting were safe and effective to prevent recurrences. Our data support further clinical trials that could compare medical and interventional therapies in patients with CIS and CaW.

Supplementary materials

Supplementary materials related to this article can be found online at https://doi.org/10.5853/jos.2020.05225.
Supplementary Table 1.
Cumulative recurrent CIE rates
Supplementary Figure 1.
Features of carotid web (CaW) on computed tomography angiography. CaW seen as a regular and thin shelf-like defect at the origin of the left carotid bulb (white arrow) on sagittal view (A), and the corresponding linear defect (white arrow) splitting the lumen artery on axial plane (B). Images of a patient with bilateral CaW (white arrows). Right asymptomatic CaW (C) and left symptomatic CaW (D) on sagittal view with the corresponding axial plane (E) that shows bilateral CaWs. Carotid bulb stenosis expressed in percentage was measured with the European Carotid Surgery Trial method: ([b - a] / b) × 100 (F).


The authors have no financial conflicts of interest.

Figure 1.
Kaplan-Meier curves of cumulative rates of cerebral ischemic event and ischemic stroke recurrences in symptomatic carotid web patients medically treated. CIE, cerebral ischemic event; IS, ischemic stroke.
Figure 2.
Illustrative case who experienced a recurrent ischemic stroke in the left MCA territory under antiplatelet treatment. Carotid web (CaW) (white arrow) on digital subtraction angiography obtained at the index event of transient right-side hemiplegia in a 42-year-old woman (A). The patient was treated with aspirin (160 mg/day). Eleven months later, the patient developed right hemiplegia and aphasia. Brain magnetic resonance imaging gradient echo sequences showed a low signal intensity lesion (white arrow) in the left middle cerebral artery (MCA) (B), and diffusion weighted imaging confirmed acute ischemic stroke in the left MCA territory (C). Sagittal (D) and axial (E) views of computed tomography angiography (CTA) showed a mural thrombus superimposed to the previously identified CaW (white arrows). Follow-up CTA obtained after anticoagulation for 2 weeks showed disappearance of the mural thrombus (white arrows): sagittal (F) and axial (G) plane.
Table 1.
Baseline characteristics of the patients
Characteristic All patients (n=92)
Age at first-ever CIE (yr) 49.3±9.7 (26-72)
Age at inclusion (yr) 49.8±9.9 (27-73)
First-ever CIE to last visit (mo) 53.2±33.6 (0.1-179)
Study enrollment to last visit (mo) 50.5±29.6 (0.1-135)
Male sex 40 (43.5)
Vascular risk factor 40 (43.5)
 Arterial hypertension 19 (20.6)
 Diabetes 3 (3.3)
 Hyperlipidemia 9 (9.8)
 Smoking 19 (20.6)
Left symptomatic CaW 48 (52.2)
Admission NIHSS 7.7±7.4 (0-27)
Admission DWI-ASPECTS* 7.2±2.5 (0-10)
Modified Rankin Scale score 0-2 at 3 months 70 (76.1)
Modified Rankin Scale score 0-2 at final follow-up visit 85 (92.4)
Index CIE
 TIA 13 (14.1)
 Acute ischemic stroke 79 (85.9)
  Superficial MCA infarction 42 (45.7)
  Deep MCA infarction 10 (10.9)
  Total MCA infarction 22 (23.9)
  Fetal disposition PCA infarction 3 (3.3)
  Retinal infarction 2 (2.2)
 Vessel occlusion 51 (55.4)
  Anterior cerebral artery 2 (2.2)
  M1 MCA 30 (32.6)
  M2 MCA 13 (14.1)
  M3 MCA 2 (2.2)
  Internal cerebral artery 4 (4.3)
Silent cerebral infarcts ipsilateral to CIE 7 (7.6)
ECST stenosis (%) 36±14 (10-90)
ESCT stenosis >35% 42 (45.6)
Presence of contralateral CaW 42 (45.6)
Carotid surgery or stenting 23 (25)
Values are presented as mean±standard deviation (range) or number (%).
CIE, cerebral ischemic event; CaW, carotid web; NIHSS, National Institutes of Health Stroke Scale; DWI-ASPECTS, diffusion-weighted imaging Alberta Stroke Program Early CT score; TIA, transient ischemic attack; MCA, middle cerebral artery; PCA, posterior cerebral artery; ECST, European Carotid Surgery Trial.
* Data derived from patients with MCA infarction (n=74).
Table 2.
Characteristics of patients treated with medical therapy alone and those with surgery or stenting
Characteristic Medical treatment group (n=69) Surgery/stenting treatment group (n=23) P
Age at first-ever CIE (yr) 50.4±9.5 (26-72) 45.9±9.7 (28-71) 0.020
Age at inclusion (yr) 51.1±9.9 (27-73) 46.2±9.7 (29-72) 0.020
First-ever CIE to last visit (mo) 53.1±34.6 (1-177) 55.6±28.8 (12-125) 0.560
Study enrollment to last visit (mo) 49.7±29.5 (1-136) 54.3±30.1 (3-125) 0.440
Male sex 29 (42.0) 11 (47.8) 0.800
Vascular risk factor 34 (49.3) 6 (26.1) 0.090
 Arterial hypertension 17 (24.6) 2 (8.7) 0.180
 Diabetes 3 (4.4) 0 (0) 0.730
 Hyperlipidemia 8 (11.6) 1 (4.4) 0.500
 Smoking 16 (23.2) 3 (13.0) 0.450
TIA as index CIE 12 (17.4) 1 (4.4) 0.170
Admission NIHSS 7.5±7.5 (0-27) 8.1±7.2 (0-24) 0.600
Admission DWI-ASPECTS* 7.4±2.5 (0-10) 6.5±2.2 (1-10) 0.060
Vessel occlusion 32 (46.4) 19 (82.6) 0.005
Silent cerebral infarction on first imaging 5 (7.3) 2 (8.7) 0.990
mRS score 0-2 at 3 months 52 (75.4) 18 (78.3) 0.990
mRS score 0-2 at last follow-up visit 63 (91.3) 22 (95.7) 0.820
ECST stenosis (%) 34±0.14 (10-90) 43±13 (19-74) 0.002
Presence of contralateral CaW 31 (44.9) 11 (47.8) 0.990
Ipsilateral CIE recurrence 12 (17.4) 7 (30.4) 0.290
Values are presented as mean±standard deviation (range) or number (%).
CIE, cerebral ischemic event; TIA, transient ischemic attack; NIHSS, National Institutes of Health Stroke Scale; DWI-ASPECTS, diffusion-weighted imaging Alberta Stroke Program Early CT score; mRS, modified Rankin Scale; ECST, European Carotid Surgery Trial; CaW, carotid web.
* Data derived from patients with middle cerebral artery infarction (n=74);
Recurrent CIEs occurred before surgery or stenting.
Table 3.
Characteristics of patients with recurrent CIE and those without
Characteristic No recurrence (n=73) Ipsilateral recurrence (n=19) P
Age at first-ever CIE (yr) 49.3±9.6 (26-72) 49.1±10.6 (36-71) 0.640
Age at inclusion (yr) 49.9±9.7 (27-73) 49.7±11.1 (36-72) 0.680
First-ever CIE to last visit (mo) 50.1±28.7 (0.1-127) 66.4±46.6 (6-179) 0.270
Study enrollment to last visit (mo) 49.9±28.4 (0.1-127) 54.5±34 (6-135) 0.750
Male sex 27 (37.0) 13 (68.4) 0.020
Vascular risk factor 32 (43.8) 8 (42.1) 0.990
 Arterial hypertension 16 (21.9) 3 (15.8) 0.780
 Diabetes 3 (4.1) 0 (0) 0.860
 Hyperlipidemia 5 (6.8) 4 (2.1) 0.150
 Smoking 14 (19.2) 5 (2.6) 0.710
TIA as index CIE 11 (15.1) 2 (10.5) 0.890
Admission NIHSS 8±7.7 (0-27) 6.5±6.2 (0-19) 0.570
Admission DWI-ASPECTS* 7.2±2.6 (0-10) 7.4±1.7 (5-10) 0.940
Vessel occlusion 38 (52.1) 13 (68.4) 0.300
Silent cerebral infarction on first imaging 2 (2.7) 5 (26.3) 0.003
mRS score 0-2 at 3 months 54 (74.0) 16 (84.2) 0.520
mRS score 0-2 at last follow-up visit 66 (90.4) 19 (100) 0.350
ECST stenosis (%) 36±14 (10-90) 38±13 (15-63) 0.370
Presence of contralateral CaW 34 (46.6) 8 (42.1) 0.920
Carotid surgery or stenting 16 (21.9) 7 (36.8) 0.290
Values are presented as mean±standard deviation (range) or number (%).
CIE, cerebral ischemic event; TIA, transient ischemic attack; NIHSS, National Institutes of Health Stroke Scale; DWI-ASPECTS, diffusion-weighted imaging Alberta Stroke Program Early CT score; mRS, modified Rankin Scale; ECST, European Carotid Surgery Trial; CaW, Carotid web.
* Data derived from patients with middle cerebral artery infarction (n=74);
Recurrent CIEs occurred before surgery or stenting.
Table 4.
Predictors for recurrent cerebrovascular ischemic event in patients under medical treatment: unadjusted and adjusted analyses
Characteristic Unadjusted
HR (95% CI) P HR (95% CI) P
Age at first-ever CIE (yr) 0.99 (0.94-1.04) 0.650 - -
Age at inclusion (yr) 0.99 (0.95-1.04) 0.720 - -
First-ever CIE to last visit (mo) 1.00 (0.99-1.01) 0.910 - -
Study enrollment to last visit (mo) 0.99 (0.98-1.01) 0.490 - -
Male sex 2.75 (1.03-7.33) 0.040 2.27 (0.83-6.16) 0.110
Vascular risk factor 0.82 (0.34-2.09) 0.710 - -
 Arterial hypertension 1.67 (0.48-5.81) 0.410 - -
 Diabetes 1.60 (0.21-12.13) 0.640 - -
 Hyperlipidemia 2.60 (0.84-7.98) 0.090 - -
 Smoking 1.13 (0.40-3.16) 0.820 - -
TIA as index CIE 0.60 (0.14-2.63) 0.500 - -
Admission NIHSS 1.00 (0.93-1.06) 0.950 - -
Admission DWI-ASPECTS* 1.01 (0.83-1.22) 0.930 - -
Vessel occlusion 2.19 (0.82-5.85) 0.120 - -
Silent cerebral infarction on first imaging 8.44 (2.94-24.24) <0.001 6.99 (2.40-20.40) 0.004
ECST stenosis (%) 5.71 (0.37-86.90) 0.210 - -
Presence of contralateral CaW 0.64 (0.25-1.64) 0.350 - -
HR, hazard ratio; CI, confidence interval; CIE, cerebral ischemic event; TIA, transient ischemic attack; NIHSS, National Institutes of Health Stroke Scale; DWI-ASPECTS, diffusion-weighted imaging Alberta Stroke Program Early CT score; ECST, European Carotid Surgery Trial; CaW, carotid web.
* Data derived from patients with middle cerebral artery infarction (n=74).


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