Journal of Stroke

Review

January 29, 2026

Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity

Jinyong Chung, Hyerin Oh, Dong-Seok Gwak, Dong-Eog Kim

J Stroke. 2026;28(1):1-28.

White matter hyperintensity (WMH), a common magnetic resonance imaging (MRI) marker of cerebral small-vessel disease, is associated with chronic cerebral ischemia; however, the mechanistic heterogeneity of WMH remains poorly defined....

Review

January 29, 2026

Mechanism-Oriented Treatment of Early Neurologic Deterioration in Acute Ischemic Stroke

Ji Hoe Heo, Kee Ook Lee, JoonNyung Heo, Hyun Sook Kim, Young Dae Kim, Hyo Suk Nam

J Stroke. 2026;28(1):29-45.

Early neurologic deterioration (END) is common and occurs within a few hours to days after an ischemic stroke. Traditionally, END has been treated as a collective entity, including the occurrence...

Review

January 29, 2026

Endovascular Therapy for Extensive Infarction in Acute Ischemic Stroke

Ashutosh P. Jadhav, Gisele Sampaio Silva, Xinyi Leng, Claus Z. Simonsen, Alejandro A. Rabinstein, David S. Liebeskind

J Stroke. 2026;28(1):46-57.

Acute ischemic stroke is the leading cause of permanent disability and second leading cause of death worldwide. Over the past 10 years, mechanical thrombectomy has become a powerful technique for...

Review

January 29, 2026

Clinical Application of Pharmacogenomics in Stroke Management: Current Evidence and Future Directions

Keon-Joo Lee, Minkyung Kang, Eung Joon Lee, Jaeseong Oh, Na-Young Han, Jeong-Yoon Lee, Joo-Yeon Lee, Soo Ji Lee, Stéphanie Debette, Guillaume Paré, et al.

J Stroke. 2026;28(1):58-75.

Pharmacogenomic variations may significantly influence responses to commonly prescribed stroke medications. Despite accumulating evidence, genetic testing has not yet been widely integrated into stroke care. This review summarizes current evidence...

Original Article

September 17, 2025

Patient-Specific Hemodynamic Simulation for Predicting Stroke Laterality in Cardiac Embolism

Mahbod Issaiy, Diana Zarei, David S. Liebeskind, Pouria Moshayedi

J Stroke. 2026;28(1):76-84.

Background and Purpose Cardioembolic sources account for 20%–30% of acute ischemic strokes (AIS), often with high morbidity. Conventional imaging confirms etiology retrospectively but lacks insight into the dynamic behavior of...

Original Article

January 2, 2026

Effect Modification by Total Bilirubin on the Association Between Hypertension and Cerebral Small Vessel Disease

Zhang Xia, Xueli Cai, Yingying Yang, Shan Li, Mengxing Wang, Xuan Wang, Tiemin Wei, Yongjun Wang, Yilong Wang, Yuesong Pan

J Stroke. 2026;28(1):85-96.

Background and Purpose Bilirubin has potent antioxidant, anti-inflammatory, and neuroprotective effects. Herein, we investigated whether total bilirubin (TBIL) modifies the association between hypertension and cerebral small vessel disease (CSVD). Methods Data...

Original Article

January 2, 2026

Dynamic Interactions Between Hemispheres Reveal a Compensatory Pathway for Motor Recovery in Moderate-to-Severe Subcortical Stroke

Huaxin Fan, Hewei Wang, Zhengxu Lian, Qiurong Yu, Xinran Wu, Nanyu Kuang, Benjamin Becker, Jianfeng Feng, Mingxia Fan, Lili Song, et al.

J Stroke. 2026;28(1):97-114.

Background and Purpose Therapeutic target selection in noninvasive brain stimulation for poststroke motor recovery typically relies on the interhemispheric inhibition model, which is effective for mildly affected patients but offers...

Original Article

January 29, 2026

Does the Benefit of Thrombectomy in Large Strokes Depend on Perfusion–Diffusion Mismatch? A Large Stroke Therapy Evaluation Trial Post Hoc Analysis

Adrien Ter Schiphorst, Caroline Arquizan, Guillaume Turc, Julien Labreuche, Bertrand Lapergue, David S. Liebeskind, Hilde Henon, Nasreddine Nouri, Jean-François Albucher, Christophe Cognard, et al.

J Stroke. 2026;28(1):115-125.

Background and Purpose Whether perfusion-diffusion mismatch modifies treatment effect of mechanical thrombectomy (MT) for large strokes is poorly known. To address this question, we conducted a post hoc secondary analysis...

Original Article

January 29, 2026

Corpus Callosum Integrity Predicts Functional Outcomes in Acute Stroke: A Probabilistic Structural Connectivity Study

Elena de la Calle, Carles Biarnés, Marian Martí-Navas, Esther Duarte, Andrea Morgado-Pérez, Mikel Terceño, Yolanda Silva, Santiago Medrano, Jaume Capellades, Salvador Pedraza, et al.

J Stroke. 2026;28(1):126-135.

Background and Purpose Stroke impairs cognition and movement. Although clinical severity and infarct volume can predict functional outcomes, variability in patient responses requires advanced structural and functional connectivity methods. Disconnection...

Original Article

January 29, 2026

Association Between Hyperacute Blood Pressure Lowering and Outcomes in Patients With Endovascular Thrombectomy

Jae Wook Jung, Eun Lee Ko, JoonNyung Heo, Hyungwoo Lee, Byungjae Kim, Young Dae Kim, Haram Joo, Byung Moon Kim, Dong Joon Kim, Hyo Suk Nam

J Stroke. 2026;28(1):136-149.

Background and Purpose Although blood pressure (BP) elevation is common in acute ischemic stroke, and guidelines recommend reducing systolic BP to

Original Article

January 29, 2026

Early Predictors of Long-Term Outcome in Basilar Artery Occlusion: A Post Hoc Analysis of the ATTENTION Trial

Feiyang Gao, Thanh N. Nguyen, Chao Zhang, Rui Li, Dafan Yu, Pengfei Xu, Anmo Wang, Min Chen, Wei Hu,

J Stroke. 2026;28(1):150-159.

Background and Purpose Accurately predicting long-term functional outcomes of basilar artery occlusion (BAO) remains challenging. We compared the predictive performance of the baseline, 24-hour, and 72-hour National Institutes of Health...

Original Article

January 29, 2026

Emergent Carotid Stenting During Endovascular Therapy for Isolated Cervical Internal Carotid Artery Occlusion

Christoph Riegler, João Pedro Marto, Pimrapat Gebert, Tilman Reiff, Marek Sykora, Marcin Wiącek, David Pakizer, André Araújo, Adrien ter Schiphorst, João André Sousa, et al.

J Stroke. 2026;28(1):160-171.

Background and Purpose In patients with ischemic stroke and isolated cervical internal carotid artery occlusion (c-ICA-O), endovascular therapy (EVT) can improve cerebral perfusion. To maintain vessel patency, EVT is frequently...

Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity Jinyong Chung, Hyerin Oh, Dong-Seok Gwak, Dong-Eog Kim J Stroke. 2026;28(1):1-28. Review January 29, 2026 Full text PubReader ePub PDF	Mechanism-Oriented Treatment of Early Neurologic Deterioration in Acute Ischemic Stroke Ji Hoe Heo, Kee Ook Lee, JoonNyung Heo, Hyun Sook Kim, Young Dae Kim, Hyo Suk Nam J Stroke. 2026;28(1):29-45. Review January 29, 2026 Full text PubReader ePub PDF
Endovascular Therapy for Extensive Infarction in Acute Ischemic Stroke Ashutosh P. Jadhav, Gisele Sampaio Silva, Xinyi Leng, Claus Z. Simonsen, Alejandro A. Rabinstein, David S. Liebeskind J Stroke. 2026;28(1):46-57. Review January 29, 2026 Full text PubReader ePub PDF	Clinical Application of Pharmacogenomics in Stroke Management: Current Evidence and Future Directions Keon-Joo Lee, Minkyung Kang, Eung Joon Lee, Jaeseong Oh, Na-Young Han, Jeong-Yoon Lee, Joo-Yeon Lee, Soo Ji Lee, Stéphanie Debette, Guillaume Paré, et al. J Stroke. 2026;28(1):58-75. Review January 29, 2026 Full text PubReader ePub PDF
Patient-Specific Hemodynamic Simulation for Predicting Stroke Laterality in Cardiac Embolism Mahbod Issaiy, Diana Zarei, David S. Liebeskind, Pouria Moshayedi J Stroke. 2026;28(1):76-84. Original Article September 17, 2025 Full text PubReader ePub PDF Supplementary Material	Effect Modification by Total Bilirubin on the Association Between Hypertension and Cerebral Small Vessel Disease Zhang Xia, Xueli Cai, Yingying Yang, Shan Li, Mengxing Wang, Xuan Wang, Tiemin Wei, Yongjun Wang, Yilong Wang, Yuesong Pan J Stroke. 2026;28(1):85-96. Original Article January 2, 2026 Full text PubReader ePub PDF Supplementary Material
Dynamic Interactions Between Hemispheres Reveal a Compensatory Pathway for Motor Recovery in Moderate-to-Severe Subcortical Stroke Huaxin Fan, Hewei Wang, Zhengxu Lian, Qiurong Yu, Xinran Wu, Nanyu Kuang, Benjamin Becker, Jianfeng Feng, Mingxia Fan, Lili Song, et al. J Stroke. 2026;28(1):97-114. Original Article January 2, 2026 Cited By 16 Full text PubReader ePub PDF Supplementary Material	Does the Benefit of Thrombectomy in Large Strokes Depend on Perfusion–Diffusion Mismatch? A Large Stroke Therapy Evaluation Trial Post Hoc Analysis Adrien Ter Schiphorst, Caroline Arquizan, Guillaume Turc, Julien Labreuche, Bertrand Lapergue, David S. Liebeskind, Hilde Henon, Nasreddine Nouri, Jean-François Albucher, Christophe Cognard, et al. J Stroke. 2026;28(1):115-125. Original Article January 29, 2026 Full text PubReader ePub PDF Supplementary Material
Corpus Callosum Integrity Predicts Functional Outcomes in Acute Stroke: A Probabilistic Structural Connectivity Study Elena de la Calle, Carles Biarnés, Marian Martí-Navas, Esther Duarte, Andrea Morgado-Pérez, Mikel Terceño, Yolanda Silva, Santiago Medrano, Jaume Capellades, Salvador Pedraza, et al. J Stroke. 2026;28(1):126-135. Original Article January 29, 2026 Full text PubReader ePub PDF	Association Between Hyperacute Blood Pressure Lowering and Outcomes in Patients With Endovascular Thrombectomy Jae Wook Jung, Eun Lee Ko, JoonNyung Heo, Hyungwoo Lee, Byungjae Kim, Young Dae Kim, Haram Joo, Byung Moon Kim, Dong Joon Kim, Hyo Suk Nam J Stroke. 2026;28(1):136-149. Original Article January 29, 2026 Full text PubReader ePub PDF Supplementary Material
Early Predictors of Long-Term Outcome in Basilar Artery Occlusion: A Post Hoc Analysis of the ATTENTION Trial Feiyang Gao, Thanh N. Nguyen, Chao Zhang, Rui Li, Dafan Yu, Pengfei Xu, Anmo Wang, Min Chen, Wei Hu, J Stroke. 2026;28(1):150-159. Original Article January 29, 2026 Full text PubReader ePub PDF Supplementary Material	Emergent Carotid Stenting During Endovascular Therapy for Isolated Cervical Internal Carotid Artery Occlusion Christoph Riegler, João Pedro Marto, Pimrapat Gebert, Tilman Reiff, Marek Sykora, Marcin Wiącek, David Pakizer, André Araújo, Adrien ter Schiphorst, João André Sousa, et al. J Stroke. 2026;28(1):160-171. Original Article January 29, 2026 Full text PubReader ePub PDF Supplementary Material
RNF213 p.R4810K Variant and Intracranial Atherosclerosis: Increased Risk in Obese Variant Carriers Masamitsu Takashima, Takuya Kiyohara, Kuniyuki Nakamura, Yuichi Ozaki, Fumitaka Yoshino, Go Hashimoto, Masaoki Hidaka, Noriyuki Sahara, Fumi Irie, Yoshinobu Wakisaka, et al. J Stroke. 2026;28(1):172-175. Letter to the Editor January 2, 2026 Full text PubReader ePub PDF Supplementary Material	Alcohol Consumption and the Risk of Ruptured Intracranial Aneurysms: A Differential Effect of the ALDH2 rs671 Variant A Letter to the Editor Regarding “Aldehyde Dehydrogenase 2 Gene Mutation May Reduce the Risk of Rupture of Intracranial Aneurysm in Chinese Han Population” Sudarma Bogahawaththa, Akiko Matsumoto J Stroke. 2026;28(1):176-177. Letter to the Editor January 2, 2026 Full text PubReader ePub PDF
Mechanical Thrombectomy in Patients With Acute Stroke Having Concurrent Intracranial Hemorrhage: Navigating a Clinical Dilemma Mikiya Beppu, Yohanna Kusuma, Shinichi Yoshimura, Jin Soo Lee, Bernard Yan J Stroke. 2026;28(1):178-180. Letter to the Editor January 2, 2026 Full text PubReader ePub PDF Supplementary Material	Significance of Perforating Vessels in Vertebrobasilar Territory Acute Ischemic Stroke Treated With Mechanical Thrombectomy: A Review of Cone-Beam Computed Tomography Findings and the Literature Mohamad Syafeeq Faeez Md Noh, Rajeev Shamsuddin Perisamy, Anas Tharek, Noor Hayatul Al Akmal Noralam, Muhammad Zakwan Yahya, Mohd Hanif Amran, Sin Yeat Mah, Siti Azleen Mohamad, Anna Misyail Abdul Rashid, Azliza Ibrahim, et al. J Stroke. 2026;28(1):181-186. Letter to the Editor January 29, 2026 Full text PubReader ePub PDF
How Stroke Shaped the Course of History: An Uchronian Narrative Review Gianluca De Rubeis, Sebastiano Fabiano, Luca Bertaccini, Francesca Romana Pezzella, Luca Saba, Enrico Pampana J Stroke. 2026;28(1):187-190. Letter to the Editor January 2, 2026 Full text PubReader ePub PDF	Interaction Between ALDH2 rs671 Polymorphism, Alcohol Consumption, and Ruptured Intracranial Aneurysm Risk: Clarifications and Future Perspectives A Response to Letter by Bogahawaththa et al. Siming Gui, Xiheng Chen, Dachao Wei, Youxiang Li J Stroke. 2026;28(1):191-192. Response to Letter January 2, 2026 Full text PubReader ePub PDF

	Editorial Office Department of Neurology, Asan Medical Center,Ulsan University College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Submission, status and progress, etc ⟫ E-mail: editor@j-stroke.org Website and system ⟫ E-mail: journal@m2community.co.kr Publishing company ⟫ E-mail: ka72sus@smileml.com
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